2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18057
    BVT-3498 376641-49-5 98%
    BVT-3498 (AMG-311) is an inhibitor for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
    BVT-3498
  • HY-19030
    TA-1801 88352-44-7 98%
    TA-1801 is a hypolipidemic agent.
    TA-1801
  • HY-19083
    SIM-6080 118790-68-4 98%
    SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits.
    SIM-6080
  • HY-19164
    BOF-4272 142181-44-0 98%
    BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research.
    BOF-4272
  • HY-19218
    RPR-106541 159001-35-1 98%
    RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism.
    RPR-106541
  • HY-19394
    CLX-0921 249886-47-3 98%
    CLX-0921 is an orally active PPARγ agonist with an IC50 of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.
    CLX-0921
  • HY-19425
    NS-220 377731-45-8 98%
    NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes.
    NS-220
  • HY-19690
    Ritobegron hydrochloride 476333-91-2 98%
    Ritobegron, a prodrug of the active compound, KUC-7322, is a selective β3 -adrenoceptor agonist. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    Ritobegron hydrochloride
  • HY-19859
    AMG-222 tosylate 1163719-08-1 98%
    AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete.
    AMG-222 tosylate
  • HY-24063
    Malonyl-L-Carnitine chloride 2417978-94-8 98%
    Malonyl-L-Carnitine (chloride) is an ester product.
    Malonyl-L-Carnitine chloride
  • HY-28247
    N-Formylkynurenine 1022-31-7 98%
    N-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N-formylkynurenine is catalyzed by heme dioxygenases.
    N-Formylkynurenine
  • HY-32338
    Tacalcitol monohydrate 93129-94-3 99.85%
    Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.
    Tacalcitol monohydrate
  • HY-34781
    4'-Trifluoromethyl-2-biphenyl carboxylic acid 84392-17-6 ≥98.0%
    4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent.
    4'-Trifluoromethyl-2-biphenyl carboxylic acid
  • HY-48289
    PKA/AKAP-IN-2 304888-67-3 98%
    PKA/AKAP-IN-2 (15109) is a non-peptide inhibitor of the interaction between protein kinase A (PKA) and A kinase anchoring proteins (AKAP). PKA/AKAP-IN-2 can be utilized in research related to cAMP disturbance associated diseases.
    PKA/AKAP-IN-2
  • HY-69262
    2-(Hexadecyloxy)-1,3-propanediol 1931-78-8 98%
    2-(Hexadecyloxy)-1,3-propanediol (1,3-Propanediol,2-(hexadecyloxy)-) is an ester product.
    2-(Hexadecyloxy)-1,3-propanediol
  • HY-75279
    N-Acetyl-β-neuraminic acid methyl ester 22900-11-4 ≥98.0%
    N-Acetyl-β-neuraminic acid methyl ester (N-Acetyl-Neuraminic acid (Sialic acid)) is an ester product.
    N-Acetyl-β-neuraminic acid methyl ester
  • HY-76802
    Calcitriol Derivatives 2070009-24-2 99.55%
    Calcitriol Derivatives is a vitamin D3 analog.
    Calcitriol Derivatives
  • HY-A0185
    Calcium Gluceptate 29039-00-7 98%
    Calcium Gluceptate is a calcium supplement. Calcium Gluceptate can be used for hypocalcaemia research.
    Calcium Gluceptate
  • HY-B0700
    Rosiglitazone sodium 316371-83-2 98%
    Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
    Rosiglitazone sodium
  • HY-B1045
    Chlorazanil hydrochloride 2019-25-2 98%
    Chlorazanil hydrochloride is an orally effective diuretic.
    Chlorazanil hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity